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Articles from Wiley

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The latest papers in ChemPubSoc Europe
Aggiornato: 8 settimane 3 giorni fa

Near UV-Irradiation of CuO<sub>x</sub>-Impregnated TiO<sub>2</sub> Providing Active Species for H<sub>2</sub> Production Through Methanol Photoreforming

25 luglio, 2019 - 00:00

Always the sun! CuO active species undergo in situ dynamic nanostructuring, through dissolution and photodeposition, changing both oxidation state and size distribution

[Full Papers]
Dr. Giuseppe Vitiello, Dr. Laura Clarizia, Dr. Wael Abdelraheem, Dr. Serena Esposito, Prof. Barbara Bonelli, Dr. Nicoletta Ditaranto, Prof. Alessandro Vergara, Prof. Mallikarjuna Nadagouda, Prof. Dionysios D. Dionysiou, Prof. Roberto Andreozzi, Prof. Giuseppina Luciani, Prof. Raffaele Marotta
doi.org/10.1002/cctc.201900818

KRAS Binders Hidden in Nature

25 luglio, 2019 - 00:00

No more undruggable targets: KRAS, the most frequently mutated oncogene in human cancers, remains undrugged, although the molecular architectures of natural products hold great promise for new drug targets. By using an integrated approach to natural product screening, the tricyclic indolopyrrole fungal alkaloid and an indoloisoquinolinone were uncovered, which bind to the active form of oncogenic RAS. This approach also holds promise for other “undruggable” targets.

[Communications]
Dr. Andreas Bergner, Dr. Xiaoling Cockcroft, Dr. Gerhard Fischer, Dr. Andreas Gollner, Wolfgang Hela, Roland Kousek, Dr. Andreas Mantoulidis, Dr. Laetitia J. Martin, Dr. Moriz Mayer, Barbara Müllauer, Gabriella Siszler, Bernhard Wolkerstorfer, Dr. Dirk Kessler, Dr. Darryl B. McConnell
doi.org/10.1002/chem.201902810

Two-Photon Absorption and Cell Imaging of Fluorene-Functionalized Epicocconone Analogues

25 luglio, 2019 - 00:00

Modification of the skeleton of epicocconone by replacing the triene side chain by a fluorenyl scaffold can noticeably increase the fluorophore's absorption coefficient. Two-photon absorption cross-section measurements of the fluorenyl epicocconone analogues show a structure-dependency with values ranging from 60 to 280 GM and live cell imaging shows intense staining of intracellular vesicle-like structures around the nucleus (see figure).

[Full Papers]
Dr. Samuel Oger, Damien Schapman, Dr. Romain Mougeot, Dr. Stéphane Leleu, Dr. Noëlle Lascoux, Dr. Patrice Baldeck, Dr. Magalie Bénard, Dr. Thibault Gallavardin, Dr. Ludovic Galas, Dr. Xavier Franck
doi.org/10.1002/chem.201902731

Quinoxaline and Pyrido[<i>x</i>,<i>y</i>-<i>b</i>]pyrazine-Based Emitters: Tuning Normal Fluorescence to Thermally Activated Delayed Fluorescence and Emitting Color over the Entire Visible-Light Range

25 luglio, 2019 - 00:00

Full rainbow of emission: Pyrido[2,3-b]pyrazine, pyrido[3,4-b]pyrazine, and quinoxaline are utilized to develop new light-emitting compounds. Through an appropriate combination of donor and acceptor, it is possible to tune the normal fluorescence into thermally activated delayed fluorescence, and tune the light emission from pure blue to green, yellow, and orange-red (see figure).

[Full Papers]
Tingting Huang, Prof. Dr. Di Liu, Prof. Dr. Jingyang Jiang, Prof. Dr. Wenfeng Jiang
doi.org/10.1002/chem.201902116

Cyanide-Free One-Pot Synthesis of Methacrylic Esters from Acetone

25 luglio, 2019 - 00:00

Methacrylic esters were synthesized in a one-pot synthesis from acetone, chloroform, and various alcohols using acetonitrile or benzonitrile as a solvent. The reaction is also applicable to bromoform and other carbonyl compounds. Deuterated methyl methacrylate was also easily produced. The reaction described herein provides a new synthetic route for methyl methacrylate production from readily available starting materials.

[Full Papers]
Minoru Koyama, Dr. Takafumi Kawakami, Dr. Takashi Okazoe, Prof. Dr. Kyoko Nozaki
doi.org/10.1002/chem.201901933

Effects of Spacers on Photoinduced Reversible Solid-to-Liquid Transitions of Azobenzene-Containing Polymers

25 luglio, 2019 - 00:00

In the spotlight: The influence of the spacer (R in the figure) on photoinduced solid-to-liquid transitions of azopolymers is investigated. Whereas azopolymers with moderate spacer length exhibit photoinduced solid-to-liquid transitions, azopolymers with short and long spacers do not. Healing scratches with light is demonstrated on hard coatings made from azopolymers and followed in real time.

[Full Papers]
Dr. Philipp Weis, Andreas Hess, Gunnar Kircher, Dr. Shilin Huang, Dr. Günter K. Auernhammer, Dr. Kaloian Koynov, Prof. Hans-Jürgen Butt, Prof. Si Wu
doi.org/10.1002/chem.201902273

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB

25 luglio, 2019 - 00:00

Adding to the toolbox: The screening of an in-house library against M. tuberculosis H37Rv identified azaaurones as novel antimycobacterial agents. In particular, several N-acetylazaaurones displayed MIC99 values in the sub-micromolar range and were found to be active against MDR and XDR-TB clinical isolates. Although the primary mechanism of action remains undetermined, azaaurones stand as promising leads for further optimization.

[Full Papers]
André Campaniço, Dr. Marta P. Carrasco, Dr. Mathew Njoroge, Ronnett Seldon, Prof. Kelly Chibale, Dr. João Perdigão, Prof. Isabel Portugal, Prof. Digby F. Warner, Prof. Rui Moreira, Prof. Francisca Lopes
doi.org/10.1002/cmdc.201900289

A Pyropheophorbide Analogue Containing a Fused Methoxy Cyclohexenone Ring System Shows Promising Cancer-Imaging Ability

25 luglio, 2019 - 00:00

Sensible sensitizers: We show that the photophysical properties, tumor specificity, uptake, imaging, and PDT efficacy of pyropheophorbide-based compounds can be heavily influenced by the nature of the exocyclic ring present in the system. We observed encouraging tumor uptake and PET contrast in tumor-bearing BALB/c mice by [124I]4, which contains a fused cyclohexenone ring. This provides easy access to a PET imaging agent with no skin phototoxicity for imaging cancer types in which the standard [18F]fluorodeoxyglucose has limitations.

[Full Papers]
Dr. Aimee J. Marko, Mykhaylo Dukh, Dr. Nayan J. Patel, Joseph R. Missert, Prof. Dr. Tymish Ohulchanskyy, Walter A. Tabaczynski, Dr. Kei Ohkubo, Prof. Dr. Shunichi Fukuzumi, Prof. Dr. Rutao Yao, Prof. Dr. Munawwar Sajjad, Prof. Dr. Ravindra K. Pandey
doi.org/10.1002/cmdc.201900352

Synthesis of Substituted 5′-Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73

25 luglio, 2019 - 00:00

Adenosine “diphospho-mimetic” analogues: Novel nucleotide analogues based on a 5′-aminoadenosine scaffold were synthesized, and their ability to inhibit the dephosphorylating 5′-ectonucleotidase CD73 was assessed. Their biological activity was then rationalized through molecular modeling studies. Considering the published data related to the design of nucleotide analogues as CD73 inhibitors, these results will aid in future SAR studies and in the further development of novel derivatives in this compound class.

[Full Papers]
Rayane Ghoteimi, Dr. Van Tai Nguyen, Dr. Rahila Rahimova, Felix Grosjean, Emeline Cros-Perrial, Dr. Jean-Pierre Uttaro, Prof. Christophe Mathé, Dr. Laurent Chaloin, Dr. Lars Peter Jordheim, Dr. Suzanne Peyrottes
doi.org/10.1002/cmdc.201900348

Divergent Synthesis and Evaluation of the in vitro Cytotoxicity Profiles of 3,4-Ethylenedioxythiophenyl-2-propen-1-one Analogues

25 luglio, 2019 - 00:00

Better on vinyl: A series of thiophene-containing vinyl ketones inspired by bioactive chalcone derivatives was synthesized and evaluated for their anticancer activity. Molecular docking with Chk2 kinase and a variety of cell-based and biochemical assays showed the most promising compound to be a vinyl ketone flanked by 3,4-ethylenedioxythiophene and 3,4,5-trimethoxyphenyl moieties.

[Full Papers]
Dr. Jayachandran Karunakaran, Nachiappan Dhatchana Moorthy, Somenath Roy Chowdhury, Saleem Iqbal, Hemanta K. Majumder, Dr. Krishnasamy Gunasekaran, Dr. Elangovan Vellaichamy, Dr. Arasambattu K. Mohanakrishnan
doi.org/10.1002/cmdc.201900225

Stereoselective Alkyne Hydrogenation by using a Simple Iron Catalyst

25 luglio, 2019 - 00:00

Simple but effective: A catalyst comprised of commercial iron(II) acetylacetonate and diisobutylaluminum hydride enables the Z-selective semihydrogenation of alkynes in high yields and with high stereocontrol. Neither elaborate catalyst preparation nor addition of ligands is required. Mechanistic studies indicate the operation of small Fe cluster catalysts.

[Full Papers]
Bernhard J. Gregori, Felix Schwarzhuber, Simon Pöllath, Prof. Dr. Josef Zweck, Lorena Fritsch, Dr. Roland Schoch, Prof. Dr. Matthias Bauer, Prof. Dr. Axel Jacobi von Wangelin
doi.org/10.1002/cssc.201900926

CO<sub>2</sub> Decomposition in CO<sub>2</sub> and CO<sub>2</sub>/H<sub>2</sub> Spark-like Plasma Discharges at Atmospheric Pressure

25 luglio, 2019 - 00:00

A bright spark: A spark-like atmospheric pressure plasma discharge is ignited in pure CO2 and in CO2/H2 mixtures to investigate CO formation. In pure CO2, the efficiency ranged between 20-50 % for CO2 conversions between 9-18 % for gas residence times of 100-600 ms. Conversion rates in CO2/H2 mixtures are found to be similar to pure CO2 at equivalent residence times. However, the outlet gas was found to produce O2-free mixtures of CO/H2/CO2 when H2 was present.

[Full Papers]
Dr. Seán Kelly, Prof. James A. Sullivan
doi.org/10.1002/cssc.201901744

Efficient Electrocatalytic CO<sub>2</sub> Reduction Driven by Ionic Liquid Buffer-Like Solutions

25 luglio, 2019 - 00:00

Isn't it ionic? A simple ionic liquid/DMSO/H2O solution is able to decrease the overpotential in a commercial electrode by in situ formation of bicarbonate, providing an alternative way to produce syngas from CO2.

[Full Papers]
Dr. Wellington D. G. Gonçalves, Dr. Marcileia Zanatta, Dr. Nathalia M. Simon, Luciane M. Rutzen, Prof. Dr. Darren A. Walsh, Prof. Dr. Jairton Dupont
doi.org/10.1002/cssc.201901076

Metallic-State SnS<sub>2</sub> Nanosheets with Expanded Lattice Spacing for High-Performance Sodium-Ion Batteries

25 luglio, 2019 - 00:00

Bloating, but the good kind: Intercalation of Ni into SnS2 results in 2D nanosheets with expanded lattice spacing and a defect-rich structure, resulting in a change in electron density and energy band structure. The resulting electrode structure, composed of vertically aligned nanosheets, exhibits shorter paths for ion insertion and extraction, larger contact area for more diffusion pathways, and superior electrolyte penetration.

[Full Papers]
Xiao Shi, Shan-Liang Chen, Hai-Ning Fan, Prof. Xiao-Hua Chen, Dingwang Yuan, Qunli Tang, Aiping Hu, Dr. Wen-Bin Luo, Prof. Hua-Kun Liu
doi.org/10.1002/cssc.201901355

Fluoridated Iron-Nickel Layered Double Hydroxide for Enhanced Performance in the Oxygen Evolution Reaction

25 luglio, 2019 - 00:00

Boosted by fluorination: The temperature dependence of the crystal structure and surface chemical state for simple fluoridation of an iron-nickel layered double hydroxide (LDH) is demonstrated for the electrochemical oxygen evolution reaction. The improved performance can be mainly attributed to the phase-structure transfer from metal−O bonding in the FeNi-LDHs to metal−F bonding after fluoridation.

[Full Papers]
Chengang Pei, Ying Gu, Zong Liu, Dr. Xu Yu, Prof. Ligang Feng
doi.org/10.1002/cssc.201901153

Rose Bengal Immobilized on Supported Ionic-Liquid-like Phases: An Efficient Photocatalyst for Batch and Flow Processes

25 luglio, 2019 - 00:00

Immobilized Rose Bengal: Polymers containing imidazolium units are excellent and tunable supports enhancing the stability and activity of Rose Bengal as a photooxidation catalyst under batch and flow conditions.

[Full Papers]
David Valverde, Raul Porcar, Diana Izquierdo, M. Isabel Burguete, Dr. Eduardo Garcia-Verdugo, Prof. Santiago V. Luis
doi.org/10.1002/cssc.201901533

Selective Cellulose Hydrogenolysis to Ethanol Using Ni@C Combined with Phosphoric Acid Catalysts

25 luglio, 2019 - 00:00

Cellulose conversion into ethanol: Ethanol is obtained through one-pot cellulose hydrogenolysis over graphene-layers-encapsulated nickel catalysts with the aid of H3PO4 in water. This work, for the first time, demonstrates a chemocatalytic approach for a high-yield production of ethanol from biomass using a non-noble metal catalyst.

[Full Papers]
Dr. Qiying Liu, Dr. Haiyong Wang, Dr. Haosheng Xin, Dr. Chenguang Wang, Dr. Long Yan, Dr. Yingxiong Wang, Dr. Qi Zhang, Dr. Xinghua Zhang, Dr. Ying Xu, Prof. George W. Huber, Prof. Longlong Ma
doi.org/10.1002/cssc.201901110

Positive Surface Pseudocapacitive Behavior-Induced Fast and Large Li-ion Storage in Mesoporous LiMnPO<sub>4</sub>@C Nanofibers

25 luglio, 2019 - 00:00

Lithium storage: One-dimensional (1D) LiMnPO4@C nanofibers with in situ-created 3D mesoporous architecture are reported, and the charge-storage behavior is addressed. Remarkably, the hierarchical construction promotes the pseudocapacitive contributions. The diffusion-controlled battery-type and surface-controlled capacitive faradaic redox processes act synergistically, giving new insights into Li-storage cathode materials to reach the goal of high energy and power densities simultaneously.

[Full Papers]
Hao Yang, Dr. Jingyuan Liu, Xiaofei Wang, Chengcheng Zhao, Prof. Lina Wang, Prof. Yonggang Wang, Prof. Yongyao Xia, Prof. Tianxi Liu
doi.org/10.1002/cssc.201901377

Strongly Coupled Interface Structure in CoFe/Co<sub>3</sub>O<sub>4</sub> Nanohybrids as Efficient Oxygen Evolution Reaction Catalysts

25 luglio, 2019 - 00:00

Interesting interface: The coupled interface structure obtained through rational design endows a CoFe layered double hydroxide (LDH)/Co3O4(6:4) nanohybrid with significantly boosted activity and durability, as well as accelerated reaction kinetics for the oxygen evolution reaction (OER).

[Full Papers]
Ping Ma, Dr. Haidong Yang, Yutong Luo, Dr. Yang Liu, Yan Zhu, Dr. Sha Luo, Dr. Yiping Hu, Dr. Ziming Zhao, Prof. Dr. Jiantai Ma
doi.org/10.1002/cssc.201901424

Photocatalytic Oxygenation Reactions Using Water and Dioxygen

25 luglio, 2019 - 00:00

As green as it gets: Water (H2O) is the most environmentally benign reductant and is oxidized to evolve dioxygen (O2)—the greenest oxidant—in photosystem II. This Minireview focuses on photocatalytic oxygenation of substrates with H2O as an oxygen source and O2 as an oxidant.

[Minireviews]
Prof. Dr. Shunichi Fukuzumi, Prof. Dr. Yong-Min Lee, Prof. Dr. Wonwoo Nam
doi.org/10.1002/cssc.201901276

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