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Articles from Wiley

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The latest papers in ChemPubSoc Europe
Aggiornato: 12 settimane 5 ore fa

Functional Characterization of 3-Aminobenzoic Acid Adenylation Enzyme PctU and UDP-<i>N</i>-Acetyl-<span class="smallCaps">d</span>-Glucosamine: 3-Aminobenzoyl-ACP Glycosyltransferase PctL in Pactamycin Biosynthesis

20 agosto, 2019 - 00:00

Start as you mean to go on: The adenylation enzyme PctU activates 3-aminobenzoic acid (3ABA) and ligates it with a discrete acyl carrier protein to yield 3ABA-PctK in early-stage pactamycin biosynthesis. Next, the glycosyltransferase PctL catalyzes the N-glycosylation of 3ABA-PctK with uridine diphosphate-N-acetyl-D-glucosamine (GlcNAc) to yield GlcNAc-3ABA-PctK as the initial ACP-bound biosynthetic intermediate.

[Communications]
Prof. Dr. Fumitaka Kudo, Jiahao Zhang, Shusuke Sato, Dr. Akane Hirayama, Prof. Dr. Tadashi Eguchi
doi.org/10.1002/cbic.201900239

Efficient Site-Specific Antibody-Drug Conjugation by Engineering a Nature-Derived Recognition Tag for Microbial Transglutaminase

20 agosto, 2019 - 00:00

Novel recognition sequences of a microbial transglutaminase derived from natural substrates were evaluated for fast, efficient, and site-specific production of antibody-drug conjugates. An optimized sequence displayed superior conjugation efficiency in the context of an antibody fusion compared to previously used recognition tags.

[Full Papers]
Aileen Ebenig, Dr. Norbert Egon Juettner, Lukas Deweid, Dr. Olga Avrutina, Dr. Hans-Lothar Fuchsbauer, Prof. Dr. Harald Kolmar
doi.org/10.1002/cbic.201900101

Heterostructured Nickel-Cobalt Selenide Immobilized onto Porous Carbon Frameworks as an Advanced Anode Material for Urea Electrocatalysis

20 agosto, 2019 - 00:00

A team effort: Heterostructured Ni−Co−Se nanocrystals were successfully immobilized onto CNTs outer walls via a one-pot-hydrothermal method in presence of hydrazine ions. The tubular structure and robust mechanical reinforcement of the support not only improve the electric conductivity but also ensure better structure stability during electrochemical reaction. As anode material for urea electrooxidation, the nanohybrid exhibits a significantly improved electrocatalytic performance benefiting from the collaborative effects of all components.

[Articles]
Dr. Diab Khalafallah, Chong Ouyang, Dr. Mingjia Zhi, Prof. Zhanglian Hong
doi.org/10.1002/celc.201900844

Dynamic Impedance Spectroscopy of Nickel Hexacyanoferrate Thin Films

20 agosto, 2019 - 00:00

Watch them evolve: The kinetics of the (de-)intercalation of univalent cations in NiHCF thin films which is unstable in its oxidized form is studied using dynamic multi-frequency analysis (DMFA). DMFA allows for the acquisition of time resolved impedance making it suitable for studying unstable or evolving electrochemical systems.

[Articles]
Collins Erinmwingbovo, Dominique Koster, Dr. Doriano Brogioli, Prof. Fabio La Mantia
doi.org/10.1002/celc.201900805

Expanded Porphyrin Contraction: From [22]Triphyrin(6.6.0) to [22]Triphyrin(6.5.0)

20 agosto, 2019 - 00:00

Shrinking of a hybrid: A metal-free expanded aromatic triphyrin undergoes an alumina-promoted contraction. A new synthetic path leading to a unique structure has been serendipitously discovered (see figure).

[Communications]
Dr. Ewa Pacholska-Dudziak, Dr. Sandra Hojniak-Thyssen, Prof. Dr. Lechosław Latos-Grażyński
doi.org/10.1002/chem.201903181

A Near-Infrared-Controllable Artificial Metalloprotease Used for Degrading Amyloid-β Monomers and Aggregates

20 agosto, 2019 - 00:00

Alzheimer's disease: In combination of the advantages of 2D MoS2 nanomaterials and the well-defined chemical features of cobalt complex, we rationally constructed a NIR-controllable artificial metalloprotease (MoS2-Co). This compound circumvented the β-sheet structures restrictions by simultaneous inhibition of the conformational switch from the random-coil to β-sheet structures and modulation of β-sheet structures of the preformed Aβ fibrils (see figure).

[Communications]
Mengmeng Ma, Ying Wang, Nan Gao, Xinping Liu, Yuhuan Sun, Prof. Jinsong Ren, Prof. Dr. Xiaogang Qu
doi.org/10.1002/chem.201902828

<sup>19</sup>F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition

20 agosto, 2019 - 00:00

The enzymatic activity of the clinically relevant class D serine β-lactamases requires lysine carbamylation, a challenging post-translational modification to characterise in solution. We show that 19F NMR is a powerful method for studying protein carbamylation, in addition to other reversible covalent modifications, including inhibitor binding.

[Communications]
Emma van Groesen, Dr. Christopher T. Lohans, Dr. Jürgen Brem, Kristina M. J. Aertker, Prof. Dr. Timothy D. W. Claridge, Prof. Dr. Christopher J. Schofield
doi.org/10.1002/chem.201902529

Bromine-Promoted Glycosidation of Conformationally Superarmed Thioglycosides

20 agosto, 2019 - 00:00

Super sugars! Bromine-promoted glycosylation of aliphatic and sugar alcohols using highly reactive thioglycoside donors was studied. Swift reaction times, high yields, and respectable 1,2-cis stereoselectivity were observed in a majority of these glycosylations.

[Communications]
Matteo Panza, Dr. Monica Civera, Dr. Jagodige P. Yasomanee, Prof. Laura Belvisi, Prof. Alexei V. Demchenko
doi.org/10.1002/chem.201901969

Acene-Modified Small-Molecule Donors for Organic Photovoltaics

20 agosto, 2019 - 00:00

The promising power conversion efficiencies achieved from the easily synthesized acene-based small molecules and easy control of bulk heterojunction morphologies suggest that acene-based small molecules can be useful materials in organic photovoltaics.” Read more about the story behind the cover in the Cover Profile and about the research itself on page ▪▪ ff. (DOI: 10.1002/chem.201902177).

[Cover Profile]
Min Jae Sung, Jisu Hong, Hyojung Cha, Yifei Jiang, Prof. Chan Eon Park, Prof. James R. Durrant, Prof. Tae Kyu An, Prof. Soon-Ki Kwon, Prof. Yun-Hi Kim
doi.org/10.1002/chem.201902973

Acene-Modified Small-Molecule Donors for Organic Photovoltaics

20 agosto, 2019 - 00:00

Power conversion efficiencies: The morphologies and charge carrier dynamics of organic photovoltaics that incorporate new acene-modified small molecules are studied (see picture; PCBM=[6,6]-phenyl-C61-butyric acid methyl ester, PEDOT:PSS=poly(3,4-ethylenedioxythiophene)polystyrene sulfonate, ITO=indium tin oxide).

[Full Papers]
Min Jae Sung, Jisu Hong, Hyojung Cha, Yifei Jiang, Prof. Chan Eon Park, Prof. James R. Durrant, Prof. Tae Kyu An, Prof. Soon-Ki Kwon, Prof. Yun-Hi Kim
doi.org/10.1002/chem.201902177

Hierarchy in the Halogen Activation During Surface-Promoted Ullmann Coupling

20 agosto, 2019 - 00:00

The presence of carbon-bromine bonds with similar gas-phase binding energies allows the Ullmann coupling to occur via two different orientations. However, upon adsorption on Au(111), one particular type of carbon-bromine bond is preferentially cleaved, thus selecting a coupling route that leads to the formation of chiral graphene nanoribbons. Nevertheless, the occasional coupling along the second orientation also leads to the lateral fusion of the nanoribbons even at mild temperatures.

[Articles]
Néstor Merino-Díez, Dr. Alejandro Pérez Paz, Dr. Jingcheng Li, Manuel Vilas-Varela, Dr. James Lawrence, Mohammed S. G. Mohammed, Alejandro Berdonces-Layunta, Ana Barragán, Dr. Jose Ignacio Pascual, Dr. Jorge Lobo-Checa, Dr. Diego Peña, Dr. Dimas G. de Oteyza
doi.org/10.1002/cphc.201900633

Molecular Electron Density Distribution and X-Ray Diffraction Patterns of Smectic A Liquid Crystals - A Simulation Study

20 agosto, 2019 - 00:00

The influence of the molecular form factor is often neglected when calculating translational-order parameters from X-ray diffraction patterns of smectic liquid crystals. The authors calculate different X-ray diffraction patterns from identical smectic A phase snapshots using different molecular electron density distributions to investigate the influence thereof on the resulting 2D X-ray diffraction patterns. They find that the influence cannot always be neglected and discuss the implications of their results on the general assessment of smectic order from XRD patterns.

[Articles]
Christian Haege, Dr. Stefan Jagiella, Prof. Dr. Frank Giesselmann
doi.org/10.1002/cphc.201900538

Lead-Free Perovskites: Metals Substitution towards Environmentally Benign Solar Cell Fabrication

20 agosto, 2019 - 00:00

Going green: Perovskite solar cells have proven to be a strong contender in the race toward renewable energy; however, the use of Pb in the best-performing cells raises toxicity concerns, leaving researchers looking for greener alternatives. The main approaches towards the development of Pb-free perovskite materials for solar cells are summarized in this Review article.

[Reviews]
Dr. Ahmed Esmail Shalan, Dr. Samrana Kazim, Prof. Shahzada Ahmad
doi.org/10.1002/cssc.201901296

H<sub>2</sub>O<sub>2</sub> Tolerance in <i>Pseudomonas Fluorescens</i>: Synergy between Pyoverdine-Iron(III) Complex and a Blue Extracellular Product Revealed by a Nanotechnology-Based Electrochemical Approach

16 agosto, 2019 - 00:00

“Conventional methods fail to explain the ability of blue Pseudomonas fluorescens strains to cope with environments containing hydrogen peroxide, possibly owing to the heterogeneity of the system. Hydrophilic pyoverdine, the most represented siderophore of P. fluorescens, is immobilized on peculiar iron oxide nanoparticles and investigated as the electrocatalytic partner of a hydrophobic blue bacterial pigment. The molecular combination results in a selective H2O2 scavenger, revealing a hidden redox mechanism. Nanotechnology is applied to complement classical electrochemical methods for addressing a complex biological issue…“ Learn more about the story behind the research featured on the front cover in this issue's Cover Profile. Read the corresponding Communication at 10.1002/celc.201900902.

[Cover Profile]
Dr. Massimiliano Magro, Dr. Davide Baratella, Dr. Petr Jakubec, Dr. Vittorino Corraducci, Prof. Luca Fasolato, Prof. Barbara Cardazzo, Prof. Enrico Novelli, Dr. Giorgio Zoppellaro, Prof. Radek Zboril, Dr. Fabio Vianello
doi.org/10.1002/celc.201901260

Distance versus Capillary Flow Dynamics-Based Detection Methods on a Microfluidic Paper-Based Analytical Device (μPAD)

16 agosto, 2019 - 00:00

Long and short of it: Alternative detection methods have emerged to resolve the issues of optical and electrochemical detection methods on microfluidic paper-based analytical devices (see figure). Distance-based measurements and capillary flow dynamics-based measurements are two methods compared herein.

[Minireviews]
Soo Chung, Christian M. Jennings, Prof. Jeong-Yeol Yoon
doi.org/10.1002/chem.201901514

Synthesis of 12-<i>epi</i>-Protopanaxadiol and Formal Synthesis of Ginsenoside Chikusetsusaponin-LT<sub>8</sub>

16 agosto, 2019 - 00:00

For the total synthesis of protopanaxadiol: (1) an optically active trienic epoxide was submitted to Ti-(III)-mediated radical cascade to afford an original 6/6/8/5 tetracyclic structure; (2) using a “ring-by-ring” synthesis gave access to 12-epi-protopanaxadiol. 20-Hydroxydammar-24-ene-3,12-dione was also synthesized, which represents a formal synthesis of chikusetsusaponin-LT8, isolated from Panax japonicus.

[Communications]
Laurent Evanno, Damien Belotti, Edmond Toromanoff, Janine Cossy
doi.org/10.1002/ejoc.201901031

PPh<sub>3</sub>/Selectfluor-Mediated Transformation of Carboxylic Acids into Acid Anhydrides and Acyl Fluorides and Its Application in Amide and Ester Synthesis

16 agosto, 2019 - 00:00

An efficient synthesis of acid anhydrides or acyl fluorides mediated by PPh3/Selectfluor synstem is reported. Mechanistic studies show that the reaction proceeds through active species of acyloxyphosphonium ions, which can be quickly converted into the final products in situ by a second carboxylic acid or F-.

[Full Papers]
Zhen Yang, Siwei Chen, Fang Yang, Chenxi Zhang, You Dou, Qiuju Zhou, Yizhe Yan, Lin Tang
doi.org/10.1002/ejoc.201901092

Room Temperature Reversible <i>Z</i>→<i>E</i> Photoisomerization of Azobenzene Appended to Anthraquinone-Benzimidazole Based Photoswitches with Resolved n→π* Absorption Band

16 agosto, 2019 - 00:00

Photochromic behavior of modified azobenzene based organic compounds have been synthesized and studied by using UV/Vis absorption study. The investigation of light-induced hydroxyl group conversion to quinone-hydrazone tautomerization has been observed during the isomerization in higher polar solvent which was confirmed by 1H-NMR spectroscopy.

[Full Papers]
Daulat Phapale, Archana Kushwaha, Dipanwita Das
doi.org/10.1002/ejoc.201900930

Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)<sub>3</sub>]<sup>2+</sup> Core

15 agosto, 2019 - 00:00

The preparation and characterization of new RuII-containing photosensitizers, that are based on a [Ru(bipy)3]2+ core (bipy: 2,2′-bipyridine) and that are extended with methyl groups or vinyl dimethylamino groups is described. Their in-depth photophysical properties as well as (photo-)cytotoxicity against cervical cancerous HeLa cells is reported.

[Full Papers]
Johannes Karges, Olivier Blacque, Philippe Goldner, Hui Chao, Gilles Gasser
doi.org/10.1002/ejic.201900569

A Highly Stable All-Inorganic CsPbBr<sub>3</sub> Perovskite Solar Cell

15 agosto, 2019 - 00:00

In recent years, the instability of hybrid organic-inorganic halide perovskite solar cells (PSCs) has been an important challenge. This work aims to address these issues by using all-inorganic CsPbBr3 perovskite as a light absorber material.

[Full Papers]
Masood Mehrabian, Sina Dalir, Ghodrat Mahmoudi, Barbara Miroslaw, Maria G. Babashkina, Anna V. Dektereva, Damir A. Safin
doi.org/10.1002/ejic.201900562

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