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Articles from Wiley

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The latest papers in Chemistry Europe
Aggiornato: 4 giorni 22 ore fa

Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

25 giugno, 2020 - 00:00

Peptide aldehyde production : An aldehyde-releasing reductase (R) domain has been identified as part of a minimal nonribosomal peptide synthetase (NRPS) in X. indica . We also show that the R domain from the tilivalline-producing NRPS can be used in engineered synthetases to introduce an aldehyde group and subsequently produce natural and unnatural pyrazinones.

[Communications]
Andreas Tietze, Dr. Yan-Ni Shi, Dr. Max Kronenwerth, Prof. Dr. Helge B. Bode
doi.org/10.1002/cbic.202000176

Thiol-Disulfide Exchange Reaction Promoted Highly Efficient Cellular Uptake of Pyridyl Disulfide Appended Nonionic Polymers

25 giugno, 2020 - 00:00

It takes two : Pyridyl-disulfide (Py−Ds) conjugated non-ionic nontoxic polymers exhibit cellular uptake by thiol-disulfide exchange with exofacial cell-surface thiols without going through the endocytosis pathway. Control experiments establish essential role of the Py−Ds group as neither pyridine- nor an aliphatic disulfide-appended polymer shows similar cellular uptake.

[Communications]
Raju Bej, Arijit Ghosh, Dr. Jayita Sarkar, Dr. Benu Brata Das, Prof. Dr. Suhrit Ghosh
doi.org/10.1002/cbic.202000303

Conformational Selection as the Driving Force of Amyloid β Chiral Inactivation

25 giugno, 2020 - 00:00

Rippled upon reflection : Aβ-CI has been proposed to operate by forming rippled cross-β networks upon mixing of Aβ enantiomers, but the drastic kinetic effects are yet to be explained. DFT calculations showed that individual peptide strains adopt lower-strain conformations in rippled than in pleated cross-β sheets, thus suggesting that conformation selection is responsible for the observed kinetic effects.

[Full Papers]
Prof. Jevgenij A. Raskatov
doi.org/10.1002/cbic.202000237

Cu-Catalyzed Reductive <i>gem </i>-Difunctionalization of Terminal Alkynes via Hydrosilylation/Hydroamination Cascade: Concise Synthesis of α-Aminosilanes

25 giugno, 2020 - 00:00

Si(lent) N(ight) in alkyne : A Cu/TMS-dppbz-catalyzed hydrosilylation/hydroamination cascade of simple terminal alkynes with hydrosilanes and hydroxylamines proceeds chemoselectively to deliver the reductive gem -difunctionalization products, α-aminosilanes, in a single operation. Additionally, the chiral (R ,R )-Ph-BPE ligand makes the reaction asymmetric to directly form the corresponding optically active α-aminosilanes, which are Si mimics of enantioenriched α-amino acids and of interest in medicinal chemistry.

[Communications]
Soshi Nishino, Prof. Dr. Koji Hirano, Prof. Dr. Masahiro Miura
doi.org/10.1002/chem.202001799

Enantiomerically Pure Tetravalent Neptunium Amidinates: Synthesis and Characterization

25 giugno, 2020 - 00:00

Enantiopure transuranic complexes : The first structurally characterized enantiopure complexes of neptunium have been synthesized. Starting from a chloro tris(amidinate) complex unprecedented neptunium(IV) fluoro, -bromo and -azido compounds could be yielded and characterized in solution and in the solid state (see scheme).

[Communications]
Sebastian Fichter, Sebastian Kaufmann, Dr. Peter Kaden, Dr. Tobias S. Brunner, Prof. Dr. Thorsten Stumpf, Prof. Dr. Peter W. Roesky, Dr. Juliane März
doi.org/10.1002/chem.202001865

Electro-Olefination—A Catalyst Free Stereoconvergent Strategy for the Functionalization of Alkenes

25 giugno, 2020 - 00:00

Electro-Olefination : The electrocoupling between (hetero)aryls and alkenes by alkenyl-triaryl borates (ATBs) is demonstrated. ATBs are synthesized by a triple ligand exchange reaction on potassium alkenyltrifluroborates with organometallic species and directly oxidized in an electrochemical two-pot coupling towards functionalized alkenes in a stereoconvergent fashion.

[Communications]
Andreas N. Baumann, Arif Music, Jonas Dechent, Nicolas Müller, Dr. Thomas C. Jagau, Dr. Dorian Didier
doi.org/10.1002/chem.202001394

Reversible <i>N- </i>Heterocyclic Carbene-Induced α-H Abstraction in Tungsten(VI) Imido Dialkyl Dialkoxide Complexes

25 giugno, 2020 - 00:00

Time to say good bye : The N -heterocyclic carbene-induced α-H elimination in tungsten(VI) imido dialkyl dialkoxide complexes offers access to tungsten(VI) imido alkylidene monoalkyl monoalkoxide complexes in excellent yields of up to 96 %.

[Communications]
Janis V. Musso, Mathis J. Benedikter, Dr. Dongren Wang, Dr. Wolfgang Frey, Hagen J. Altmann, Prof. Dr. Michael R. Buchmeiser
doi.org/10.1002/chem.202000840

Monohydride-Dichloro Rhodium(III) Complexes with Chiral Diphosphine Ligands as Catalysts for Asymmetric Hydrogenation of Olefinic Substrates

25 giugno, 2020 - 00:00

Curious cats : Asymmetric hydrogenation of simple olefins was achieved by using monohydride-dichloro rhodium(III) complexes 1 a -c which were characterized by NMR spectroscopy, including DOSY NMR, and X-ray single crystal analysis. Among these three complexes, 1 c has a rigid pocket surrounded by two chloride atoms bound to the rhodium atom for fitting to simple olefins without any coordinating functional groups.

[Full Papers]
Dr. Kosuke Higashida, Fabian Brüning, Nagataka Tsujimoto, Kenya Higashihara, Dr. Haruki Nagae, Prof. Dr. Antonio Togni, Prof. Dr. Kazushi Mashima
doi.org/10.1002/chem.202000542

Electronic Consequences of Ligand Substitution at Heterometal Centers in Polyoxovanadium Clusters: Controlling the Redox Properties through Heterometal Coordination Number

25 giugno, 2020 - 00:00

Combined experimental and theoretical methods are used to gain fundamental understanding of the redox-properties of iron-vanadium oxo-alkoxide clusters as they related to modification of the heterometal number.

[Full Papers]
Rachel L. Meyer, Dr. Montaha H. Anjass, Brittney E. Petel, Dr. William W. Brennessel, Prof. Carsten Streb, Prof. Ellen M. Matson
doi.org/10.1002/chem.201905624

Site-Directed Antibody Immobilization by Resorc[4]arene-Based Immunosensors

25 giugno, 2020 - 00:00

The immobilization of antibodies for optimized immunosensor development has been obtained by using resorc[4]arene as site-directing tool; this makes it possible to overcome the complexity of binding an antibody to the sensor surface, avoiding the random orientation with a lower binding site density and immunoaffinity. A surface plasmon resonance (SPR) technique has been employed for the characterization of the modified surface as well as to evaluate the heterogeneous kinetics of the model insulin/insulin-Ab interaction.

[Full Papers]
Dr. Deborah Quaglio, Laura Mangiardi, Dr. Giulia Venditti, Cristina Del Plato, Francesca Polli, Dr. Francesca Ghirga, Prof. Gabriele Favero, Prof. Marco Pierini, Prof. Bruno Botta, Prof. Franco Mazzei
doi.org/10.1002/chem.202000989

Photophysics, Electrochemistry and Efficient Electrochemiluminescence of Trigonal Truxene-Core Dyes

25 giugno, 2020 - 00:00

A series of new dyes built from a spirofluorene or truxene core connected to terminal donor groups via π-conjugated linkers having thiophene moieties has been synthesized and studied. Electrochemistry indicates the formation of stable radical cations and anions related to the charge delocalization. The brightest ECL emission is obtained with the blue-emitting truxene dye by annihilation and the coreactant pathway.

[Full Papers]
Dr. Silvia Voci, Prof. Jean-Baptiste Verlhac, Dr. Federico Polo, Guillaume Clermont, Dr. Jonathan Daniel, Prof. Frédéric Castet, Dr. Mireille Blanchard-Desce, Prof. Neso Sojic
doi.org/10.1002/chem.202000474

Engineering Bifunctional Host Materials of Sulfur and Lithium-Metal Based on Nitrogen-Enriched Polyacrylonitrile for Li-S Batteries

25 giugno, 2020 - 00:00

Polyacrylonitrile (PAN) is delicately engineered as a bifunctional host material to simultaneously solve the problems of the shuttle effect in the cathode and lithium dendrite in the anode, which leads to improved electrochemical performances of both electrodes. Due to excellent bifunctional host characteristics, the full cell demonstrates an outstanding long-term cycling capability.

[Full Papers]
Zudian Dai, Mei Wang, Yin Zhang, Boya Wang, Hang Luo, Xuemei Zhang, Dr. Qian Wang, Prof. Yun Zhang, Prof. Hao Wu
doi.org/10.1002/chem.202000467

Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage

25 giugno, 2020 - 00:00

Probing ascorbate : A new, activity-based sensing strategy was developed for the highly selective detection of ascorbate. A copper(II) complex was designed to be activated by ascorbate to effect an oxidative bond cleavage and release an emissive fluorophore for a turn-on signal. The new ascorbate probes can be applied in complex matrix including food, plasma, and live cells.

[Full Papers]
Zuo Hang Yu, Christopher J. Reinhardt, Thomas Hin-Fung Wong, Ka Yan Tong, Prof. Jefferson Chan, Dr. Ho Yu Au-Yeung
doi.org/10.1002/chem.202000780

Remarkable Energy Barrier for Magnetization Reversal in 3D and 2D Dysprosium-Chloranilate-Based Coordination Polymers

25 giugno, 2020 - 00:00

CP magnets : Dysprosium(III) chloranilate (Cl2An) based coordination polymers (CPs) [{Dy(Cl2An)1.5(CH3OH)} 4.5 H2O]n (1 ) and [Dy(Cl2An)1.5(DMF)2]n (2 ) were synthesized and characterized. Magnetic investigations revealed field-induced slow magnetic relaxation behavior in both CPs. The larger ground-state QTM in 2 compared with 1 results in a higher energy barrier for magnetization reversal in the latter.

[Full Papers]
Arpan Mondal, Dr. Subhadip Roy, Prof. Dr. Sanjit Konar
doi.org/10.1002/chem.202000438

Synthesis, Structure, Reactivity and Catalytic Implications of a Cationic, Acetylide-Bridged Trigold-JohnPhos Species

25 giugno, 2020 - 00:00

Multinuclear gold : A new family of tri-AuI complexes have been characterised as intermediates during the [AuIL][SbF6] catalytic preparation of acetaldehyde acetals. These well-characterised cationic AuI intermediates lend support to the proposed reaction mechanism. An analogous copper complex revealed different behaviour, leading to a vinylphosphonium and copper nanoparticles.

[Full Papers]
Dr. Abdessamad Grirrane, Dr. Eleuterio Álvarez, Prof. Dr. Hermenegildo García, Prof. Dr. Avelino Corma
doi.org/10.1002/chem.202000420

Review and Prospect: Deep Learning in Nuclear Magnetic Resonance Spectroscopy

25 giugno, 2020 - 00:00

Applying automation : The applications of deep learning in NMR spectroscopy are summarized, and a perspective for deep learning as an entirely new approach that is likely to transform NMR spectroscopy into a much more efficient and powerful technique in chemistry and life sciences is outlined.

[Minireviews]
Dicheng Chen, Zi Wang, Prof. Di Guo, Prof. Vladislav Orekhov, Prof. Xiaobo Qu
doi.org/10.1002/chem.202000246

Evolution of High-Valent Nickela-Electrocatalyzed C−H Activation: From Cross(-Electrophile)-Couplings to Electrooxidative C−H Transformations

25 giugno, 2020 - 00:00

Go electro ! Nickela-electrocatalyzed C−H activations have emerged as a sustainable platform in molecular sciences that avoid substrate prefunctionalizations and chemical oxidants by electricity. The robust nickela-electrooxidations enabled C−C, C−O, and C−N formations with ample scope under exceedingly mild conditions.

[Reviews]
Shou-Kun Zhang, Dr. Ramesh C. Samanta, Dr. Antonio Del Vecchio, Prof. Dr. Lutz Ackermann
doi.org/10.1002/chem.202001318

Female Faculty: Why So Few and Why Care?

25 giugno, 2020 - 00:00

Diversity in academia : Data shows that there are few female faculty in academia today, with the percentage decreasing the higher the rank. There are many common responses to gender equality efforts that hamper progress of women in academia. Herein, we counteract such comments and discuss possible solutions along with concerns about how the COVID-19 pandemic may affect diversity in academia.

[Science Voices]
Prof. Dr. Shina Caroline Lynn Kamerlin, Prof. Dr. Pernilla Wittung-Stafshede
doi.org/10.1002/chem.202002522

Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2

25 giugno, 2020 - 00:00

The anti-apoptotic protein Mcl-1 and E3 ubiquitin ligase HDM2 are both frequently upregulated in cancer. A small-molecule inhibitor can be developed by mimicking their protein binding partners, Bim and p53, to restore apoptosis in oncogenic cells. Through a polypharmacology approach, we have developed small-molecule α-helix mimetics with isoxazole, pyrazole, and thiazole scaffolds that function as dual inhibitors of Mcl-1 and HDM2.

[Communications]
Ivie L. Conlon, Dr. Brandon Drennen, Dr. Maryanna E. Lanning, Samuel Hughes, Rebecca Rothhaas, Dr. Paul T. Wilder, Dr. Alexander D. MacKerell Jr., Dr. Steven Fletcher
doi.org/10.1002/cmdc.202000278

Enhancement of Negative Photochromic Properties of Naphthalene-Bridged Phenoxyl-Imidazolyl Radical Complex

25 giugno, 2020 - 00:00

A fast, switchable negative photochromic molecule is useful as a photo-switch for functional materials applications. The authors succeed in controlling the thermal back reaction rates and enhancing the visible-light sensitivity of the naphthalene-bridged phenoxyl-imidazolyl radical complex (Np−PIC). These insights will be important for the future development of fast, switchable negative photochromic molecules.

[Articles]
Hiroki Ito, Dr. Katsuya Mutoh, Prof. Jiro Abe
doi.org/10.1002/cphc.202000296

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