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Articles from Wiley

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The latest chemistry from ChemPubSoc Europe and Wiley-VCH
Updated: 6 weeks 2 days ago

In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent

3 August, 2017 - 00:00

In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent

A 64Cu-labeled cyclotide with high specificity for receptor CXCR4 was used for in vivo PET imaging of tumors with high CXCR4 expression level, showing the potential of this microprotein molecular scaffold for in vivo bio-imaging applications.

[Full Paper]
Wojciech G. Lesniak, Teshome Aboye, Samit Chatterjee, Julio A. Camarero, Sridhar Nimmagadda
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201702540 Read article

Structural Study of a New HIV-1 Entry Inhibitor and Interaction with the HIV-1 Fusion Peptide in Dodecylphosphocholine Micelles

3 August, 2017 - 00:00

Structural Study of a New HIV‐1 Entry Inhibitor and Interaction with the HIV‐1 Fusion Peptide in Dodecylphosphocholine Micelles

No admittance! The peptide E1P47 forms a helix–turn–helix motif in zwitterionic dodecylphosphocholine (DPC) micelles, a structure, which is relevant for its inhibitory activity. E1P47 interacts with the HIV-1 fusion peptide at the membrane level by interfering with those domains in the HIV-1, which are critical for stabilizing the six-helix bundle formation in a membranous environment (see figure).

[Full Paper]
Yolanda Pérez, Maria José Gómara, Eloísa Yuste, Patricia Gómez-Gutierrez, Juan Jesús Pérez, Isabel Haro
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201702531 Read article

Double-Arm Lanthanide Tags Deliver Narrow Gd<sup>3+</sup>–Gd<sup>3+</sup> Distance Distributions in Double Electron–Electron Resonance (DEER) Measurements

3 August, 2017 - 00:00

Double‐Arm Lanthanide Tags Deliver Narrow Gd3+–Gd3+ Distance Distributions in Double Electron–Electron Resonance (DEER) Measurements

Metal on a tether: Double-arm cyclen-based Gd3+ tags confine the space accessible to the metal ion (see figure) and produce accurate nanometer scale Gd3+–Gd3+ distance measurements by double electron-electron resonance (DEER) experiments, which show excellent agreement with predictions both for the maximum and width of the measured distance distributions. This research opens new opportunities to study the conformational landscape of proteins in solution.

[Full Paper]
Adarshi P. Welegedara, Yin Yang, Michael D. Lee, James D. Swarbrick, Thomas Huber, Bim Graham, Daniella Goldfarb, Gottfried Otting
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201702521 Read article

Silver(I) Clusters with Carba-<i>closo</i>-dodecaboranylethynyl Ligands: Synthesis, Structure, and Phosphorescence

3 August, 2017 - 00:00

 Synthesis, Structure, and Phosphorescence

The silver lining: Neutral, monoanionic, and dianionic silver(I) clusters stabilized by carba-closo-dodecaboranylethynyl and pyridine ligands were obtained with organic cations (see figure). Selected clusters were studied by photoluminescence spectroscopy and found to be room-temperature phosphorescent. The quantum yields were strongly influenced by the pyridine ligands.

[Full Paper]
Michael Hailmann, Natalia Wolf, Rebecca Renner, Benjamin Hupp, Andreas Steffen, Maik Finze
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201702515 Read article

Cancer Stem Cell and Bulk Cancer Cell Active Copper(II) Complexes with Vanillin Schiff Base Derivatives and Naproxen

3 August, 2017 - 00:00

Cancer Stem Cell and Bulk Cancer Cell Active Copper(II) Complexes with Vanillin Schiff Base Derivatives and Naproxen

Two birds with one copper stone: We present a series of copper(II) complexes containing vanillin Schiff base derivatives and the nonsteroidal anti-inflammatory drug, naproxen. Three of the complexes kill bulk cancer cells and cancer stem cells with similar doses. The most effective complex evokes cell death by inducing DNA damage and inhibiting cyclooxygenase-2.

[Full Paper]
Chunxin Lu, Arvin Eskandari, Paul B. Cressey, Kogularamanan Suntharalingam
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201701939 Read article

Synthesis of Copper Oxide/Graphite Composite for High-Performance Rechargeable Battery Anode

3 August, 2017 - 00:00

Synthesis of Copper Oxide/Graphite Composite for High‐Performance Rechargeable Battery Anode

Graphite composite anode: A one-step synthesis of advanced graphite/Cu oxide composites (GCuO) is developed. Thermal treatment of a Cu ion complex and graphite induces graphite interlayer expansion and Cu oxide formation. The resulting GCuO cell shows a high capacity of 532 mAh g−1 and a good stability of 83 % after 250 cycles (see figure).

[Full Paper]
Sanghun Cho, Yong-keon Ahn, Zhenxing Yin, Duck-Jae You, Hyunjin Kim, Yuanzhe Piao, Jeeyoung Yoo, Youn Sang Kim
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201701931 Read article

Glycodendrimers as Chondroitin Sulfate Mimetics: Synthesis and Binding to Growth Factor Midkine

3 August, 2017 - 00:00

 Synthesis and Binding to Growth Factor Midkine

Click for chondroitin sulfates: Dendrimers displaying CS disaccharides were efficiently synthesized. These multivalent systems showed high protein binding affinities, mimicking the activity of this biologically relevant polysaccharide.

[Full Paper]
Pedro Domínguez-Rodríguez, José J. Reina, Sergio Gil-Caballero, Pedro M. Nieto, José L. de Paz, Javier Rojo
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201701890 Read article

Ambient Water-Stable Dianionic Electron Donors: Intramolecular Noncovalent Conduits Assist Charge Delocalization

3 August, 2017 - 00:00

 Intramolecular Noncovalent Conduits Assist Charge Delocalization

Moving charges: We report the first example of an exceptionally stable naphthalenediimide-based dianion in ambient and hot water. The dianionic state was confirmed by X-ray crystallography. The noncovalent electronic conduits introduced for the first time in dianions aid in delocalizing the dianionic charge. The dianions harness strong NIR absorption and electron donor ability to organic acceptors and metal ions.

[Full Paper]
Sudhir Kumar Keshri, Sharvan Kumar, Kalyanashis Mandal, Pritam Mukhopadhyay
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201701868 Read article

A Secondary Structural Element in a Wide Range of Fucosylated Glycoepitopes

3 August, 2017 - 00:00

A Secondary Structural Element in a Wide Range of Fucosylated Glycoepitopes

Rigid sugars: NMR structure determination revealed a common 3D scaffold in 25 % of all fucose-containing carbohydrates. The central feature is a C−H⋅⋅⋅O hydrogen bond, indicated by a characteristic chemical shift. This work suggests that fucosylation of certain glycans leads to a rigidification in addition to generating glyco-epitopes for recognition events.

[Full Paper]
Thomas Aeschbacher, Mirko Zierke, Martin Smie&#x161;ko, Mayeul Collot, Jean-Maurice Mallet, Beat Ernst, Frédéric H.-T. Allain, Mario Schubert
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201701866 Read article

DFT Studies of Dimerization Reactions of Boroles

3 August, 2017 - 00:00

DFT Studies of Dimerization Reactions of Boroles

Boroles undergo dimerization reactions to give Diels–Alder (DA) dimers, bridged-bicyclic (BB) dimers or spiro dimers (SD) depending on the substituents on the borole. DFT calculations were performed to investigate how different substituents at the carbon atoms of the butadiene backbone as well as at the boron atom influence the dimerization reaction pathways.

[Full Paper]
Zheng Wang, Yu Zhou, Ka-Ho Lee, Wai Han Lam, Rian D. Dewhurst, Holger Braunschweig, Todd B. Marder, Zhenyang Lin
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201701737 Read article

Dynamic Kinetic Spiroketalization/Oxa-Michael Addition Cascade of Alkoxyboronates and Peroxyacetals: Enantio- and Diastereoselective Synthesis of Benzannulated Spiroketals

3 August, 2017 - 00:00

Dynamic Kinetic Spiroketalization/Oxa‐Michael Addition Cascade of Alkoxyboronates and Peroxyacetals: Enantio‐ and Diastereoselective Synthesis of Benzannulated Spiroketals

The first catalytic asymmetric syntheses of isobenzofuran-based benzannulated spiroketals and exo-peroxy-benzannulated spiroketals have been developed. A series of valuable chiral benzannulated spiroketals were obtained in high yields, high diastereoselectivities, and outstanding enantioselectivities (see scheme).

[Communication]
Abhisek Midya, Sanjay Maity, Prasanta Ghorai
Chem. Eur. J., August 03, 2017, https://doi.org/10.1002/chem.201701291 Read article

New Carbon Nanodots-Silica Hybrid Photocatalyst for Highly Selective Solar Fuel Production from CO<sub>2</sub>

3 August, 2017 - 00:00

New Carbon Nanodots‐Silica Hybrid Photocatalyst for Highly Selective Solar Fuel Production from CO2

Through the link: The facile and eco-friendly synthesis of highly active carbon nanodots-silica hybrid photocatalyst (CNDSH) by a reverse microemulsion method with a nonionic surfactant. The photocatalyst-biocatalyst coupled system developed using CNDSH as photocatalyst functions efficiently to carry out high NADH regeneration followed by its consumption in exclusive formic acid production from CO2.

[Full Paper]
Rajesh K. Yadav, Abhishek Kumar, No-Joong Park, Dolly Yadav, Jin-Ook Baeg
ChemCatChem, August 03, 2017, https://doi.org/10.1002/cctc.201700789 Read article

Kinetic Modeling of an Enzymatic Redox Cascade In Vivo Reveals Bottlenecks Caused by Cofactors

3 August, 2017 - 00:00

Kinetic Modeling of an Enzymatic Redox Cascade In Vivo Reveals Bottlenecks Caused by Cofactors

Model behavior: We developed a kinetic model for the simulation and optimization of an in vivo redox cascade in E. coli in which a combination of an alcohol dehydrogenase, an enoate reductase, and a Baeyer–Villiger monooxygenase was used for the synthesis of lactones. The model was used to estimate the concentrations of active enzyme in the sequential biotransformations to identify bottlenecks together with their reasons and how to overcome them.

[Full Paper]
Sofia Milker, Michael J. Fink, Nikolin Oberleitner, Anna K. Ressmann, Uwe T. Bornscheuer, Marko D. Mihovilovic, Florian Rudroff
ChemCatChem, August 03, 2017, https://doi.org/10.1002/cctc.201700573 Read article

Two Completely Different Mechanisms for Highly Specific Na<sup>+</sup> Recognition by DNAzymes

3 August, 2017 - 00:00

Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes

In a bind: Two DNAzymes, EtNa and Ce13d, are compared to elucidate their mechanisms of Na+ binding. Both DNAzymes bind Na+ with excellent specificity but with different mechanisms. Ce13d binds one Na+ through a well-defined Na+ aptamer motif, and EtNa binds two Na+ ions mainly by way of a scissile phosphate without significant involvement of the nucleotides in the enzyme strand.

[Full Paper]
Wenhu Zhou, Runjhun Saran, Jinsong Ding, Juewen Liu
ChemBioChem, August 03, 2017, https://doi.org/10.1002/cbic.201700184 Read article

Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A

2 August, 2017 - 00:00

Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A

Pop the cap: Two new fluorogenic aptasensors based on capped mesoporous silica nanoparticles for the detection of ochratoxin A (OTA) are prepared. The presence of OTA induces displacement of the aptamer from the solid surface, opens the pores, and selectively releases dye (see figure). These new capped nanomaterials allow accurate determination of OTA in realistic wheat samples and may allow the development of a simple test for the detection of OTA in food samples.

[Full Paper]
Àngela Ribes, Sara Santiago-Felipe, Andrea Bernardos, M. Dolores Marcos, Teresa Pardo, Félix Sancenón, Ramón Martínez-Máñez, Elena Aznar
ChemistryOpen, August 02, 2017, https://doi.org/10.1002/open.201700106 Read article

Hydroiodination-Triggered Cascade Reaction with I<sub>2</sub>/PPh<sub>3</sub>/H<sub>2</sub>O: Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates

2 August, 2017 - 00:00

Hydroiodination‐Triggered Cascade Reaction with I2/PPh3/H2O: Metal‐Free Access to 3‐Substituted Phthalides from 2‐Alkynylbenzoates

Phthalides are synthesized in excellent yields by a metal-free cascade reaction from 2-alkynylbenzoates with I2/PPh3/H2O, which are readily available reagents. This reaction includes four steps: desilylation, hydroiodination, cyclization, and reduction.

[Communication]
Shin-ichi Kawaguchi, Kentaro Nakamura, Kotaro Yamaguchi, Yuki Sato, Yuhei Gonda, Masaaki Nishioka, Motohiro Sonoda, Akihiro Nomoto, Akiya Ogawa
Eur. J. Org. Chem., August 02, 2017, https://doi.org/10.1002/ejoc.201700839 Read article

Application of a Metal-Mediated Base Pair to the Detection of Medicinally Relevant Single Nucleotide Polymorphisms

2 August, 2017 - 00:00

Application of a Metal‐Mediated Base Pair to the Detection of Medicinally Relevant Single Nucleotide Polymorphisms

Read more about the story behind the cover in the Cover Profile and about the research itself on page -- ff (https://doi.org/10.1002/ejic.201700665).

[Cover Profile]
Biswarup Jash, Jens Müller
Eur. J. Inorg. Chem., August 02, 2017, https://doi.org/10.1002/ejic.201700881 Read article

Near Infra-Red S<sub>0</sub>↔T<sub>1</sub> Transitions of Iridium(III) Phthalocyanine: Degeneracy of the T<sub>1</sub> State Evidenced by Magnetic Circular Dichroism

2 August, 2017 - 00:00

 Degeneracy of the T1 State Evidenced by Magnetic Circular Dichroism

The lowest excited triplet (T1) state of an iridium(III) phthalocyanine (IrPc) complex was investigated by electronic absorption, magnetic circular dichroism (MCD), and emission spectroscopy. The Faraday A term was successfully observed for the S0[RIGHTWARDS ARROW]T1 transition in the MCD spectrum, indicating the degeneracy of the T1 state.

[Communication]
Kei Murata, Kazuyuki Ishii
Eur. J. Inorg. Chem., August 02, 2017, https://doi.org/10.1002/ejic.201700668 Read article

Replacement of Biphenyl by Bipyridine Enabling Powerful Hole Transport Materials for Efficient Perovskite Solar Cells

2 August, 2017 - 00:00

Replacement of Biphenyl by Bipyridine Enabling Powerful Hole Transport Materials for Efficient Perovskite Solar Cells

Bip, bip: Bipyridine is introduced for the first time as the core structure for new hole transport materials (HTMs). Remarkable power conversion efficiencies of 17.71 and 18.48 % are achieved in conventional planar perovskite (CH3NH3PbI3−xClx) solar cells by using the newly devised HTMs.

[Full Paper]
Fei Wu, Yahan Shan, Jianhui Qiao, Cheng Zhong, Rui Wang, Qunliang Song, Linna Zhu
ChemSusChem, August 02, 2017, https://doi.org/10.1002/cssc.201700973 Read article

Anionic Extraction for Efficient Recovery of Biobased 2,3-Butanediol—A Platform for Bulk and Fine Chemicals

2 August, 2017 - 00:00

Anionic Extraction for Efficient Recovery of Biobased 2,3‐Butanediol—A Platform for Bulk and Fine Chemicals

Complex separation: Microbial production of 2,3-butanediol based on renewable resources enables high titers; however, the recovery of this hydrophilic high-boiling compound from aqueous fermentation broths remains challenging. Anionic extraction based on reversible esterification with phenylboronate is proposed for the isolation of 2,3-butanediol from aqueous solutions. The recovered bio-2,3-butanediol can be efficiently transformed into methyl ethyl ketone.

[Full Paper]
Peter Drabo, Till Tiso, Benedikt Heyman, Eda Sarikaya, Paula Gaspar, Jochen Förster, Jochen Büchs, Lars Mathias Blank, Irina Delidovich
ChemSusChem, August 02, 2017, https://doi.org/10.1002/cssc.201700899 Read article

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