slideshow 16 slideshow 1 slideshow 2 slideshow 3 slideshow 4 slideshow 5 slideshow 6 slideshow 7 slideshow 8 slideshow 0 slideshow 9 slideshow 10 slideshow 11 slideshow 12 slideshow 13 slideshow 14 slideshow 15

Articles from Wiley

Syndicate content
The latest papers in ChemPubSoc Europe
Updated: 4 weeks 2 days ago

Base-Assisted Electrografting of Aromatic Amines

5 August, 2019 - 00:00

Basicity is a strength: The role of organic bases in surface modification through the oxidation of aromatic amines is clarified and a grafting efficiency index is proposed to help choose the most suitable base. With strong bases, the covalent attachment of aromatic amines can occur at almost the open-circuit potential.

[Communications]
Corentin Anex, Dr. Ewen Touzé, Léonard Curet, Dr. Frédéric Gohier, Dr. Charles Cougnon
doi.org/10.1002/celc.201900979

Ratiometric DNA Walking Machine for Accurate and Amplified Bioassay

5 August, 2019 - 00:00

Don′t run before you can walk! A ratiometric DNA walking machine was developed based on the elemental isotope ratio measurement. The target DNA-triggered walking machine converted and amplified biological signals into mass spectrometric signal ratios (197Au/115In) by a burnt-bridge mechanism (see scheme).

[Communications]
Chaoqun Wang, Prof. Rui Liu, Jianyu Hu, Prof. Yi Lv
doi.org/10.1002/chem.201903034

Chirality-Controlled Self-Assembly of Amphiphilic Dibenzo[6]helicenes into Langmuir-Blodgett Thin Films

5 August, 2019 - 00:00

“…we have observed an interesting behaviour of bare amphiphilic helicenes in Langmuir layers and Langmuir-Blodgett films that is controlled by molecular chirality and the nature of the polar group.” Read more about the story behind the cover in the Cover Profile and about the research itself on page ▪▪ ff. (DOI: 10.1002/chem.201901695).

[Cover Profile]
Jan Holec, Dr. Jiří Rybáček, Dr. Jaroslav Vacek, Dr. Manfred Karras, Dr. Lucie Bednárová, Dr. Miloš Buděšínský, Michaela Slušná, Dr. Petr Holý, Prof. Bernd Schmidt, Dr. Irena G. Stará, Dr. Ivo Starý
doi.org/10.1002/chem.201903286

Photoinitiated Charge Transfer in a Triangular Silver(I) Hydride Complex and Its Oxophilicity

5 August, 2019 - 00:00

Inspired by previous studies on multinuclear silver hydrides and our work on bimetallic phosphine-stabilized compounds, we extended the nuclearity by designing a trimetallic system that allows for direct optical excitation of a metal-centered chromophore.” Read more about the story behind the cover in the Cover Profile and about the research itself on page ▪▪ ff. (DOI: 10.1002/chem.201901981).

[Cover Profile]
Sebastian V. Kruppa, Cedric Groß, Xin Gui, Florian Bäppler, Björn Kwasigroch, Dr. Yu Sun, Prof. Dr. Rolf Diller, Prof. Dr. Wim Klopper, Prof. Dr. Gereon Niedner-Schatteburg, Dr. Christoph Riehn, Prof. Dr. Werner R. Thiel
doi.org/10.1002/chem.201903111

The Distinct Conformational Landscapes of 4<i>S</i>-Substituted Prolines That Promote an <i>endo</i> Ring Pucker

5 August, 2019 - 00:00

Conformational control: 4S-Substituted prolines with electron-withdrawing 4-substitutents strongly promote the endo ring pucker and the δ conformation central to β-turns (ϕ, ψ=−80°, 0°), as determined by X-ray crystallography and calculations. This work suggests their broader application in protein design, medicinal chemistry, and catalysis.

[Full Papers]
Nicholas V. Costantini, Dr. Himal K. Ganguly, Maxwell I. Martin, Nicole A. Wenzell, Prof. Dr. Glenn P. A. Yap, Prof. Dr. Neal J. Zondlo
doi.org/10.1002/chem.201902382

Isolation and Crystallographic Characterization of Two, Nonisolated Pentagon Endohedral Fullerenes: Ho<sub>3</sub>N@<i>C</i><sub>2</sub>(22010)-C<sub>78</sub> and Tb<sub>3</sub>N@<i>C</i><sub>2</sub>(22010)-C<sub>78</sub>

5 August, 2019 - 00:00

Purified samples of Ho3N@C2(22010)-C78 and Tb3N@C2(22010)-C78 have been isolated from fullerenes and endohedral fullerenes present in carbon soot from graphite rods doped with Ho2O3 or Tb4O7. Crystallographic analysis of the endohedral fullerenes as cocrystals with Ni(OEP) shows that both molecules contain the chiral C2(22010)-C78 cage, which does not obey the isolated pentagon rule but has two sites where two pentagons share a common C−C bond (see figure).

[Full Papers]
Prof. Dr. Steven Stevenson, Amanda J. Rothgeb, Katelyn R. Tepper, Prof. Dr. James Duchamp, Prof. Dr. Harry C. Dorn, Xian B. Powers, Mrittika Roy, Prof. Dr. Marilyn M. Olmstead, Prof. Dr. Alan L. Balch
doi.org/10.1002/chem.201902559

Lithium-Bromide Exchange versus Nucleophilic Addition of Schiff's base: Unprecedented Tandem Cyclisation Pathways

5 August, 2019 - 00:00

Book-breaking boundaries: Standard textbook methodology of rapid, selective lithium-bromide exchange has been challenged in the case of bromo-substituted imines. Employing tert-butyllithium (tBuLi), five products are identified, revealing an unprecedented competitive nucleophilic addition pathway, along with tandem inter/intra-molecular cyclisations.

[Full Papers]
Dr. Samantha A. Orr, Dr. Emily C. Border, Prof. Philip C. Andrews, Dr. Victoria L. Blair
doi.org/10.1002/chem.201902140

Preparation of (Pentafluorosulfanyl)benzenes by Direct Fluorination of Diaryldisulfides: Synthetic Approach and Mechanistic Aspects

5 August, 2019 - 00:00

Taking the direct route: Direct fluorination of substituted aromatic disulfides or thiols provided arylsulfur pentafluorides (see scheme). The scope and limitation of the direct fluorination for the synthesis of new SF5-containing building blocks is described. The mechanism of the second step was investigated computationally.

[Full Papers]
Javier Ajenjo, Dr. Blanka Klepetářová, Dr. Martin Greenhall, Dr. Daniel Bím, Dr. Martin Culka, Dr. Lubomír Rulíšek, Dr. Petr Beier
doi.org/10.1002/chem.201902651

Bis(merocyanine) Hetero-Folda-Dimers: Evaluation of Exciton Coupling between Different Types of π-Stacked Chromphores

5 August, 2019 - 00:00

Exciting coupling: Three well-defined hetero-dye stacks comprising two chromophores are obtained upon folding of bis(merocyanine) dyes in nonpolar solvents. Theoretical investigations reveal a strong coupling between the dyes’ transition dipole moments within the dye stacks leading to significant changes of the absorption properties upon aggregation, which can be rationalized by molecular exciton theory.

[Full Papers]
Dr. Eva Kirchner, Dr. David Bialas, Prof. Frank Würthner
doi.org/10.1002/chem.201901757

Bis(merocyanine) Homo-Folda-Dimers: Evaluation of Electronic and Spectral Changes in Well-Defined Dye Aggregate Geometries

5 August, 2019 - 00:00

Facing stacks: Folding of three bis(merocyanine) dyes comprising chromophores of different conjugation lengths leads to cofacial π-stacks of two chromophores. Hence, detailed studies on the electronic and spectral changes of the chromophores upon aggregation are enabled.

[Full Papers]
Dr. Eva Kirchner, Dr. David Bialas, Marius Wehner, Dr. David Schmidt, Prof. Frank Würthner
doi.org/10.1002/chem.201901754

σ-Silane Platinum(II) Complexes as Intermediates in C−Si Bond-Coupling Processes

5 August, 2019 - 00:00

Intermediacy of σ-SiH PtII complexes: Primary silanes are shown to form σ-SiH complexes with cationic electron-deficient PtII complexes, [Pt(NHC′)(NHC)]+ (see graphic). These compounds evolve at room temperature through a double Si−H bond activation process that involves the formation of C−Si and Si−Pt bonds with concomitant extrusion of H2. Localized orbital analysis has revealed enhanced silylium character of the silicon atom when the silyl fragment is located at the apical position, which presumably favors the C−Si coupling event.

[Full Papers]
Pablo Ríos, Hugo Fouilloux, Dr. Josefina Díez, Dr. Pietro Vidossich, Prof. Dr. Agustí Lledós, Dr. Salvador Conejero
doi.org/10.1002/chem.201902226

Aminomethyl Transfer (Mannich) Reactions Between an O-Triethylsilylated Hemiaminal and Anilines, R<sub><i>n</i></sub>C<sub>6</sub>H<sub>5−<i>n</i></sub>NH<sub>2</sub> Leading to New Diamines, Triamines, Imines, or 1,3,5-Triazines Dependent upon Substituen

5 August, 2019 - 00:00

The reactions of the Mannich reagent Et3SiOCH2NMe2 with a variety of anilines (mono-substituted RC6H4NH2, R=H, 4-CN, 4-NO2, 4-Ph, 4-Me, 4-MeO, 4-Me2N; R2C6H3NH2; di-substituted R2=3,5-(CH3)2, 3,5-(CF3)2; R3C6H2NH2; tri-substituted R3=3,5-Me2-4-Br; and a “super bulky” aniline (Ar*NH2) [Ar*=2,6-bis(diphenylmethyl)-4-tert-butylphenyl]) have been investigated. These led to the formation of di- and triamines, as well as 1,3,5-triazines, or imines, depending on the substituent.

[Full Papers]
Anwar Jacintomoreno, Dr. Hemant K. Sharma, Dr. Alejandro Metta-Magaña, Prof. Dr. Keith H. Pannell
doi.org/10.1002/chem.201901877

Direct Synthesis of N-Heterocyclic Carbene-Stabilized Copper Nanoparticles from an N-Heterocyclic Carbene-Borane

5 August, 2019 - 00:00

Carbene-stabilized NPs: N-Heterocyclic carbene (NHC)-stabilized copper nanoparticles (NPs, see figure) were synthesized in toluene from mesitylcopper and an NHC-borane reagent, which plays a dual role of contributing to the reduction of [CuMes]2 to release Cu0 species and providing NHC ligands to stabilize the Cu NPs. The one-step reaction is quantitative with respect to the copper precursor.

[Full Papers]
Dr. Xavier Frogneux, Dr. Laura Hippolyte, Dr. Dimitri Mercier, Dr. David Portehault, Prof. Corinne Chanéac, Prof. Clément Sanchez, Prof. Philippe Marcus, Dr. François Ribot, Prof. Louis Fensterbank, Dr. Sophie Carenco
doi.org/10.1002/chem.201901534

Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

5 August, 2019 - 00:00

The geometry of design: A comparative study of two sets of new amphiphiles revealed a large difference in detergent efficacy for membrane-protein stabilization between terphenyl-cored maltosides (TPMs) with bent and linear structures (TPM-Vs and TPM-Ls, respectively; see figure). This result indicates the importance of detergent hydrophobic group geometry in membrane-protein stability.

[Full Papers]
Dr. Muhammad Ehsan, Dr. Yang Du, Jonas S. Mortensen, Dr. Parameswaran Hariharan, Qianhui Qu, Lubna Ghani, Dr. Manabendra Das, Anne Grethen, Prof. Bernadette Byrne, Prof. Georgios Skiniotis, Prof. Sandro Keller, Prof. Claus J. Loland, Prof. Lan Guan, Prof. Brian K. Kobilka, Prof. Pil Seok Chae
doi.org/10.1002/chem.201902468

Evolutionary Algorithm-Based Crystal Structure Prediction for Copper(I) Fluoride

5 August, 2019 - 00:00

Ever evolving: Evolutionary crystal structure prediction algorithms combined with dispersion-corrected hybrid density functional calculations yield a large number of new low-energy structural candidates for the unknown copper(I) fluoride.

[Full Papers]
Dr. Mikhail S. Kuklin, Prof. Lorenzo Maschio, Dr. Denis Usvyat, Prof. Dr. Florian Kraus, Prof. Antti J. Karttunen
doi.org/10.1002/chem.201902314

Mechanochemical Pretreatment for Efficient Solvent-Free Synthesis of SSZ-13 Zeolite

5 August, 2019 - 00:00

Activation by milling led to the solvent-free synthesis of SSZ-13 zeolite with a huge gain in terms of product/gel ratio. The automatized pretreatment process performed by planetary mill resulted in successful synthesis, whereas the manual mechanochemical approach failed.

[Full Papers]
Dr. Veronika Pashkova, Dr. Kinga Mlekodaj, Dr. Petr Klein, Dr. Libor Brabec, Dr. Radek Zouzelka, Dr. Jiri Rathousky, Dr. Venceslava Tokarova, Dr. Jiri Dedecek
doi.org/10.1002/chem.201902107

Photoinitiated Charge Transfer in a Triangular Silver(I) Hydride Complex and Its Oxophilicity

5 August, 2019 - 00:00

Spin, charge, reactivity! The triangular silver(I) hydride complex [Ag3(μ3-H)(μ2-dcpm)3]2+ (dcpm=bis(dicyclohexylphosphino)methane, see figure) features multinuclear coupling between 1H, 31P, and 109Ag/107Ag, and UV-induced hydride-to-Ag3 charge transfer. Electronic transitions have been predicted by high-level electronic structure calculations and experimentally evidenced by the observed photoinduced fragments. ESI-MS revealed activation-specific dissociation pathways.

[Full Papers]
Sebastian V. Kruppa, Cedric Groß, Xin Gui, Florian Bäppler, Björn Kwasigroch, Dr. Yu Sun, Prof. Dr. Rolf Diller, Prof. Dr. Wim Klopper, Prof. Dr. Gereon Niedner-Schatteburg, Dr. Christoph Riehn, Prof. Dr. Werner R. Thiel
doi.org/10.1002/chem.201901981

Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety

5 August, 2019 - 00:00

It's not the hydroxamate! Antibacterial LpxC inhibitors have been optimized for enzymatic potency, anti-pseudomonal activity, pharmacokinetics, and cardiovascular safety. We demonstrate that the much-maligned hydroxamic acid is not responsible for the cardiovascular toxicity observed with LpxC inhibitors. The development of a phosphate prodrug enabled high solubility and rapid conversion into active drug upon intravenous administration.

[Full Papers]
Dr. Frederick Cohen, Dr. James B. Aggen, Dr. Logan D. Andrews, Dr. Zahra Assar, Jen Boggs, Dr. Taylor Choi, Dr. Paola Dozzo, Ashton N. Easterday, Dr. Cat M. Haglund, Darin J. Hildebrandt, Melissa C. Holt, Kristin Joly, Dr. Adrian Jubb, Dr. Zeeshan Kamal, Timothy R. Kane, Dr. Andrei W. Konradi, Kevin M. Krause, Martin S. Linsell, Dr. Timothy D. Machajewski, Olga Miroshnikova, Dr. Heinz E. Moser, Dr. Vincent Nieto, Thu Phan, Dr. Craig Plato, Dr. Alisa W. Serio, Julie Seroogy, Dr. Anton Shakhmin, Dr. Adam J. Stein, Dr. Alex D. Sun, Dr. Serguei Sviridov, Zhan Wang, Kenneth Wlasichuk, Dr. Wen Yang, Dr. Xiaoming Zhou, Dr. Hai Zhu, Dr. Ryan T. Cirz
doi.org/10.1002/cmdc.201900287

Photoinduced Energy- and Electron-Transfer Processes in a <i>Side-to-Face</i> Ru<sup>II</sup>-Porphyrin/Perylene-bisimide Array

5 August, 2019 - 00:00

A side-to-face array based on perylene bisimide sandwiched between two RuII-porphyrins is prepared and characterized from the photophysical viewpoint, showing a wavelength-dependent behavior. Photoinduced electron transfer takes place upon “red light” excitation of the perylene unit, while energy transfer occurs upon “green light” excitation of the RuII-porphyrin complex.

[Articles]
Dr. Agnese Amati, Dr. Mirco Natali, Prof. Dr. Maria Teresa Indelli, Prof. Dr. Elisabetta Iengo, Prof. Dr. Frank Würthner
doi.org/10.1002/cphc.201900611

Bubble Solution Description by Non-Extensive Thermodynamics: Pressure Effect

5 August, 2019 - 00:00

A generalized version of Henry's Law for (nano)bubbles with ill-defined geometrical boundaries is proposed:

[Articles]
Prof. Pierre Letellier, Dr. Mireille Turmine
doi.org/10.1002/cphc.201900412

Copyright © 2012 Società Chimica Italiana. All Rights Reserved.